الفهرس | Only 14 pages are availabe for public view |
Abstract This study was done on twenty five patients with chronic renal failure on regular hemodialysis. The mean value of their ages was 44.1 ± 8.5 years and the mean value of their duration of dialysis was 2.8 ± 2.2 years. The following findings were reported in this study: 1-Gastro-duodenal angiodysplasia was found in 32% of the study group at the start of work and 62.5% of them were bleeding (melaena ± hamatemesis) 2-Cases with angiodysplasia showed microcytic hypochromic anemia more than cases without it due to more risk recurrent bleeding. 3-Cases with angiodysplasia showed no bleeding tendency than cases without it more 4-Cases with angiodysplasia showed no significant difference ln biochemical parameters measured including: fasting blood sugar, blood urea, serum creatinine, serum calcium and serum phosphate. 5-Cases with angiodysplasia showed higher serum aluminum levels (evidenced by BAL) and higher - 147- body stores of aluminum (evidenced by DAL) than cases without it. 6-Prevalence of angiodysplasia is higher with higher serum aluminum level and with longer duration of dialysis. 7-Decreasing serum aluminum level by administration of Dfo led to significant improvement of angiodysplasia as it was detected in l2% of the studied group at the end of the work. So, it is concluded that: A} Angiodysplasia of the upper gastrointestinal tract is an important cause of upper gastrointestinal hemorrhage in patients with chronic renal failure on regular hemodialysis. B) Aluminum accumulation in the body of these patients may be responsible for the development of angiodysplasia. |