الفهرس 
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Abstract
Male androgenetic alopecia is the most common form of hair loss in men. It is characterized by progressive hair loss starting from vertex that gradually progresses inwards. AGA is an androgen-dependant trait which leads to progressive miniaturization of the hair follicle in predisposed men. AGA is a multifactorial disorder caused by interactions between hormonal, genetic, oxidative stress, and environmental factors.
Paraoxonase 1 is a calcium-dependent enzyme which related to HDL. PON1 plays an important role as an antioxidant in preventing oxidation of LDL. PON1 also acts as anti-inflammatory, anti-oxidative, anti-atherogenic, anti-diabetic and anti-microbial. PON1 has the same activity as peroxidase because it is effective on lipid peroxides and hydrogen peroxide.
Low-density lipoprotein oxidation was stimulated by excessive production of ROS and reactive nitrogenous species. If the circulating LDL level is high, the antioxidants in the body are insufficient to maintain the antioxidant protection of LDL which oxidizes rapidly. High levels of LDL promote the binding of nitric oxide with hydrogen peroxide to produce peroxynitrite which is a powerful oxidant and constantly attacks endothelial cells resulting in endothelial dysfunction.
The aim of the present study was to measure the serum PON1 in male AGA patients and compare its level with healthy controls. This case control study included sixty male patients complaining of AGA and twenty age and sex healthy volunteers as a control. They were selected from those attending the Outpatient Clinic of Dermatology, Venereology and Andrology Department of Benha University Hospitals. The study was conducted from April 2020 to December 2021.