الفهرس 
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Abstract
This prospective, randomized, double-blind study was held at EL-Minia University Hospital between October 2021 and April 2023, the study involved 80 patients ASA grade II mild pre-eclamptic women, admitted for elective cesarean section under spinal anesthesia. At the end of surgery, an ultrasound-guided Quadratus lumborum block was given to each patient. Written informed consent was gained from each patient.
This study aimed to evaluate the effect of adding magnesium sulphate to bupivacaine for quadratus lumborum block on the duration of the postoperative analgesia.
Patients were randomly divided into two equal groups; group C (control group, n=40) received 22.5 mL solution containing Bupivacaine only for each side of quadratus lumborum block at the end of cesarean section. group M (Magnesium group, n=40) received 22.5 mL solution containing bupivacaine plus 250 mg magnesium sulphate for each side of quadratus lumborum block at the end of cesarean section.
All patients were assessed with regards to:
Time to first analgesic request (in minutes) and total analgesic consumption (in mg) of nalbuphine required were recorded in the two groups for 48 hours in ward.
Pain assessment using a scoring system based on the (VAS) consisting of (best to worst: 0 – 10 cm) both at rest and on movement (static VAS and dynamic VAS) was measured during first 48 hours postoperatively.
Hemodynamics (heart rate, SAP, DAP and MAP) and oxygen saturation changes were recorded either intraoperatively or during the first 48 hours postoperatively.
Patient satisfaction score was recorded.
Possible complications were reported during the operation and for 48 hours postoperatively.
The results of this study reported that demographic (age, weight, height and parity) and surgical data (duration of surgery and time of motor recovery) were statistically insignificant between the two groups of patients.
As regard time to first analgesic request, it was significantly longer in magnesium group than control group. Also the total analgesic requirement postoperatively was significantly lower in the magnesium group than the control group.
Both static and dynamic Visual Analogue Scales (VAS) were better in the magnesium group than in the control group during the study period.
Hemodynamics (heart rate, SAP, DAP and MAP) and oxygen saturation were statistically insignificant between the two groups at all-time intervals (pre-, intra- and post-operative).
Patient satisfaction score was better in magnesium group patients than control group patients.
As regard the complications (nausea, vomiting, hypotension and shivering), there were no statistical significant differences between the two groups.
Conclusion
The study concluded that adding magnesium sulfate to bupivacaine for quadratus lumborum block for cesarean section in women with mild pre-eclampsia resulted in a prolonged time to first analgesic request, reduced total analgesic consumption, and improved VAS scores for pain at rest and on movement with minimal side effects.