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العنوان
Pattern of Skeletal Muscle Involvement in Systemic Sclerosis and Systemic Lupus Erythematosus Patients /
المؤلف
Mohamed, Asmaa Kotb.
هيئة الاعداد
باحث / أسماء قطب محمد
مشرف / أمل علي حسن
مشرف / مني حمدي محمود
مشرف / مصطفي محمد مصطفي
الموضوع
Rehabilitation medicine. Cardiology.
تاريخ النشر
2024.
عدد الصفحات
207 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الروماتيزم
تاريخ الإجازة
4/3/2024
مكان الإجازة
جامعة المنيا - كلية الطب - الروماتيزم و التأهيل
الفهرس
Only 14 pages are availabe for public view

from 222

from 222

Abstract

Assessment was conducted through a medical history, physical examination, lab work, radiologic, electromyographic (EMG), and muscle biopsy procedures.
In systemic sclerosis (SSc) patients 29 (96.7%) had arthralgia, 8 patients (26.7%) had arthritis and 15 (50%) had myalgia. Disease activity was determined using the Modified Rod Nan Skin Score (MRSS) ranged from 3 to 37 with a mean of 14.8±7.9. Also mild thickening was found in 5 (16.7%) patients, moderate thickening was found in 14(46.7%) patients and severe thickening was found in 11(36.7%) patients.
The prevalence of muscle affection on vastus lateralis was 13(43.3%)patients, deltoid was 12(40%), followed by tibialis anterior 3(10%). The prevalence of clinical muscle weakness 1(3.3%), EMG muscle affection was 13(43.7%), muscle biopsy affection was 14(46.7%). Significantly, there was positive relationship between illness duration and arthralgia A notable negative correlation was found amid age with ESR. Patients’ CRP and aldolase levels with inflammation showed a substantial negative correlation. A significant negative correlation was observed between the patient’s aldolase levels with degenerative muscle fiber and there was positive significant correlation between patient’s ALT with Increased insertional activity. Positive and significant correlations were found between the patients with minimal contraction and with maximal contraction with vasculitis.
In systemic lupus erthrymatoues (SLE) 25 patients (83.3%) had arthralgia and 16 patients (53.3%) had arthritis and 17(56.7%) had myalgia. Disease activity was measured by SLEDAI2K activity ranged from 2 to 15 with a mean of 6.13±3.06. 18(60%)patients with mild disease activity, 8(26.7%) moderately active disease and 4(13.3%) having a serious illness.
The prevalence of muscle affection on vastus lateralis was 12(40%)patients, deltoid was 11(36.7%), followed by tibialis anterior 2(6.7%). The prevalence of clinical muscle weakness 1(3.3%), EMG muscle affection was 15(50%), muscle biopsy affection was 15(50%). Additionally, there was positive statistically important correlation between age of the patient and sex with hemoglobin and TLC. The length of the disease and the patient’s age showed a positive, significant correlation with increased insertional activity.