الفهرس 
Introduction
Chapter 1: Helicobacter PyloriOnly 14 pages are availabe for public view
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Abstract
This research aims to provide insight on the relationship between obesity, the hormones leptin and adiponectin, and Helicobacter pylori infection.
In the present study, 150 participants 50 diagnosed as obese patient without H. pylori infection and also 50 obese with H. pylori infection section of Mallway General Hospital, Minya governate, Egypt. Fifty age-matched healthy controlss were also included. Filling out a questionnaire prepared to fulfil the research needs for H. pylori positive, negative, obese, and controls needed a meeting and interview. The study’s protocol was approved by Chemistry Department, Faculty of Science, Minia University and by committee of ”The Research Ethics Committee (P.No.MPEC (230201))”.
The included participates were separated into three groups: a healthy control group; obese patients with and without H. pylori infection; and obese patients without infection. Blood was collected and approximately 1.5 ml Serum was separated and used for the finding out of H. Pylori IgG, lipid profile (total cholesterol, triglycerides, HDL-c, LDL-c concentration), ALT, AST, urea, creatinine, leptin, adiponectin, stool H. Pylori Ag was also estimated.
The obtained data of the above mentioned investigations revealed the following:
• HDL-c and adiponectin exhibited a similar behavioral pattern, since they were decreased in obese Patients with and without H. pylori infection and increased in healthy control group.
• Serum leptin, on the other hand, were profoundly increased in obese pateints Whether infected or uninfected with Helicobacter pylori and normal in healty control group.
• Obese patients marked increases of serum total cholesterol (TC), triglycerides (TGs) and LDL were observed, while the concentration of HDL-cholesterol was decreased. The healthy control group show normal serum lipid variables.
• Enzymes of Liver (ALT and AST) levels were elevated in serum of obese patients whether infected or uninfected with Helicobacter pylori. The healthy control group show normal serum of both tested enzymes.
• Non-significant change in serum creatinine and blood urea in 3 studied groups.
• H. Pylori infection was positively correlated with: BMI, total cholesterol, triglycerides, LDL-c in both of two whether infected or uninfected with Helicobacter pylori, in addition, correlated positively with: leptin both of two obese groups with and without H. pylori infection.
• Leptin levels were positively correlated with H. pylori IgG, total cholesterol, and total fat levels in obese individuals with and without H. pylori infection.
• Whether infected or not with Helicobacter pylori, adiponectin had a negative connection with H. pylori IgG, TC, and TG in obese individuals.
In Conclusion, the data we’ve collected suggests that Leptin and Adiponectin concentrations in obese individuals dissimilar to those in people with normal BMI. Normal body mass index individuals (BMI) were compared to those obese individuals had a disrupted adipocytokine profile, which included a markedly higher leptin concentration and a lower level of adiponectin. Additionally, there is no discernible a distinction between adipocytokine levels (including Adiponectin and leptin) between people with and without H. pylori.