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Abstract
Hepatitis C virus (HCV) affects more than 170 million people and causes an estimated 460,000 deaths per year. A small proportion of patients are able to clear this infection, but most become carriers and may eventually develop chronic liver diseases, including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Was to find out the effect of aerobic exercise on immunity indices in chronic HCV patients without any complains. 30 patients with chronic hepatitis C, both sex (13 men and 17 women), were selected from the outpatient of liver centre at benha fever hospital. They were divided into two groups equal in number, group A (study group) received an aerobic exercise in form of walking on electronic treadmill three times per week for 3 months, in addition to their medical treatment. group B (control group) received their medical treatment only .Their mean age was (40 - 50 years old) .In the study, using flow cytometry ”BD Facscalibur ” two colure for measurement of natural killer cells for expression (CD₃⁺CD₅₆⁺) was used for all patients in both groups before and after the study. There was statistical significant increase in natural killer cells (CD₃⁺,CD₅₆⁺) in study group after performing aerobic exercise for 3 months by 32.18% improvement compared with control group receiving medical treatment only. The outcomes of the present study emphasized that the use of aerobic exercise to improve immunity indices by increasing of natural killer cells in chronic HCV patients