الفهرس 
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Abstract
Many studies were conducted on acute ischemic stroke patients and relation between the severity and outcome of these patients and serum level of Vitamin D. They revealed that patients with low vitamin D level had more severe and worse outcome and major disability during follow up, while patients with normal serum vitamin D level had better outcome.
Few studies were conducted about the relation between serum vitamin D level and acute ischemic stroke patients treated with thrombolysis.
The aim of the present study was to explore the relationship between serum vitamin D level and severity and functional outcome in acute ischemic stroke patients treated with thrombolysis.
The present study was conducted on 66 patients diagnosed with acute ischemic stroke in the therapeutic window and treated with intravenous rt-PA with a mean age 60.6±10.2 years.
Severity of stroke of the included patients was assessed by National Institute of Health Stroke Score (NIHSS) on admission, after 24 hours from thrombolysis, after 1 week of the onset of stroke also, follow up of outcome and short-term disability using modified Rankin Scale (mRS).
Infarction size was measured using thepure ellipsoid model of ABC/2.
All patients included in our study had been measured for Vitamin D level after at least 8 hours of fasting in the early morning using commercial double antibody sandwich enzyme linked immunosorbent assay (25 OHVD ELISA).
The results of our study were summarized in the following:
1) The mean value for Vitamin D level was 29.45±13.84.
2) There was no statistically significant difference between vitamin D deficient and patients with normal serum vitamin D level regarding NIHSS at the onset.
3)There was statistically significant difference between both groups regarding mRS, which confirms the role of vitamin D on the outcome and disability of stroke patients treated with thrombolysis.
4)There was a statistically significant difference between vitamin D deficient and patients with normal vitamin D level treated with rt-PA regarding incidence of complications related to rt-PA (intracerebral hemorrhage or cerebral edema).
5)There was strong negative correlation between patients age and serum vitamin D level.
6) Approximately 44 % of patients (n=29) had vitamin D level more than or equal 30 ng/ml while 56 % of patients (n= 37) had Vitamin D level less than 30 ng/ml.
7) There was negative correlation between Serum Vitamin D level and NIHSS at the onset of stroke but did not reach a significant value.
8) There was negative correlation between serum vitamin D level and serum cholesterol but not significant.
9) There was negative correlation between TGs level and serum vitamin D level but did not reach significant value
10) There was negative correlation between serum vitamin D level and pulmonary hypertension.
11) There was a significant moderate linear negative correlation between serum vitamin D level and size of the infarction.
12) There was a significant moderate linear negative correlation between serum vitamin D level and NIHSS at day 2,7 from the onset of stroke
13) There was a significant moderate linear correlation between serum vitamin D level and mRS.
14) There was a significant linear positive correlation between patient`s age and mRS.
15) there was a significant linear strong correlation between vitamin D level and the percent of decrease of NIHSS score.
16) There was a significant association between low vitamin D level and complications after rt-PA (poor functional outcome)
17)There was negative correlation between vitamin D level and recurrence of stroke.
18)There was a significant role of vitamine D in prediction of occurrence of complication of rt-PA at a cut off ≤17 with sensitivity 75%, specificity 82%, PPV 25% and NPV 98%.
19)Complications from rt-PA injection (malignant cerebral edema and Intracerebral hemorrhage) for rt-PA treated patients occurred in 27.7 % of patients (n=18), while 72.7% of patients (n=48) were not complicated.
20)There was no significant correlation between BMI and serum vitamin D level.
21)There was no statistically significant correlation between serum vitamin D level and left atrial dilatation.