الفهرس 
Chapter 1: Review of literatureOnly 14 pages are availabe for public view
 |  | from | 162 |  |  |
| | | from | 162 | | |
Abstract
Preeclampsia is the gestational hypertensive disorder of the highest morbidity and mortality.
It demonstrates long-term maternal and fetal consequences that develop far beyond gestation. Disrubted RAS is attested to contribute to PE pathogenesis.
Recently demonstrated, pregnant women are prone to rapid progression to endotoxemia, a multifaceted clinical state associated with grave consequences.
Cardiomyopathy constitutes a major complication that contributes to the elevated mortality rate of endotoxic shock.
In the current work, pharmacologic and immunohistochemical studies were employed to evaluate whether preeclamptic programming alters the inflammatory and cardiovascular consequences of endotoxemia in both postpartum mothers and adult offspring along with the related neuroinflammatory state in brainstem cardiovascular-sensitive pools.
The work also evaluated the RAS modulators as potential therapeutic strategies for dampening down manifestations of the preeclamptic - endotoxic interaction.
Experiments were conducted in conscious freely moving male rats pre-instrumented with femoral intravascular catheters