الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Bile acids constitute one of the most frequently suggested molecules as indicators or predictorsfor hepatobiliary insufficiency or disease (Luo et al., 2018).Bile acids constitutemore than 20 bile acids synthesized by the liver as primary bile acids Cholic acid (CA) andchenodeoxycholic acid (CDCA) which are then modified by intestinal bacteria into secondary bile acidsdeoxycholic acid (DCA), lithocholic acid (LCA), and ursodeoxycholic acid (UDCA). Conjugation of the bile acids through the enterohepatic circulation results in more water-soluble bile acids and thus protecting against hepatic cellular damage from the toxic hydrophobic bile acids, which can induce oxidative stress and cell death signaling (Altekruse et al., 2009). Since BA synthesis and metabolism are affected by liver diseases, the BAs and their composition have been studied and utilized as diagnostic and prognostic markers. However, it has been unclear how the etiologies of liver diseases affect the BA composition. In this regard the present study aimed to investigate the serum BA compositions, including the levels of primary, secondary and conjugated BAs, using LC-MS/MS in a large number of patients with different etiologies of liver diseases. This study was conducted on 250 patients with different liver diseases In addition; 50 apparently healthy individuals matching age and gender of the patients who served as a control group.