الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Orthotropic liver transplantation (OLT) became the standard of care
for patients with decompensated cirrhosis and for patients with
hepatocellular carcinoma. Nowadays 9.6% of total Egyptian liver
transplantation surgeries are performed in National Liver Institute & high
graft survival rates have been achieved in great part due to the availability
of potent immunosuppressive agents.
Unfortunately, systemic immunosuppression has rendered the liver
recipient susceptible to de novo infections as well as reactivation of
preexisting latent infections which occurr during the first month post-
OLT especially fungal infections.
The most common post transplant fungal infections are Candida
infections, which range from superficial oral candidiasis to life
threatening invasive blood candidiasis.
Recognizing infections in transplant recipients is difficult; clinical
signs and symptoms are often not specific and might be muted &fever is
a nonspecific symptom. At the same time, differentiating infective from
no infective causes requires thorough clinical evaluation, diagnostic
procedures, and radiologic imaging for an appropriate diagnosis
Given the increased risk and poor outcomes in liver transplant
recipients who develop fungal infections, early diagnosis and aggressive
antifungal prophylaxis should be considered upfront in high-risk patients
& so improve outcomes.
The aim of this study was to determine the incidence of Candida
infection among liver transplantation recipients in National Liver
Institute, evaluate the value of mannan antigen assay in early detection.