الفهرس 
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Abstract
The thesis is divided into seven parts:-
Part I: A general introduction about anticoagulant drugs, their classification and their pharmacological actions.
Part II: New validated spectrofluorimetric and spectrophotometric methods for the determination of clopidogrel (CLP) in pure form and pharmaceutical preparations depending on ion-pair complex formation with eosin without need for prior extraction with organic solvent.Part III:The aim of this part is to develop a highly sensitive and valid method for determination of a binary mixture of rivaroxaban (RIV) and clopidogrel (CLP) and its application to biological fluids (plasma and urine).
Part IV:A highly sensitive new validated fluorescence quenching based procedure for the determination of cilostazol and clopidogrel was discussed and applied for bulk, tablets and biological fluids. Stern volmer equation was applied to determine if the quenching procsss is dynamic or static. Part V: This part divided into two main partitions: The first is an accurate and highly sensitive RP-HPLC method for simultaneous determination of cilostazol and dipyridamole in pharmaceuticals and biological fluids. The second depends on using derivative spectrophotometry for simultaneous assay of both mentioned drugs in pure form and pharmaceuticals. Part VI: Determination of cilostazol in presence of its oxidative degradation product and co formulated Telmisartan. Also, first derivative spectrophotometric method was developed for determination of cilostazol in presence of its oxidative degradation product with high selectivity. Part VII: Rivaroxaban and clopidogrel were determined using three spectrophotometric methods. The method was applied for determination of both drugs in their synthetic mixture and laboratory prepared tablet with successful results.