الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The first chapter includes introduction about coumarins, chalcones, nitric oxide moiety. The scope of investigation states the main objectives of synthesis of a group of different hybrids gathering coumarin-chalcone, 7-hydroxycoumarin derivatives-Chalcone or chalcone moieties with the NO donor oxime and determination of the amount of nitric oxide release per time. The third chapter contains different methods were used for the synthesis of the designed coumarin-chalcone hybrids, coumarin-chalcone NO donor hybrids and chalcone-NO donor hybrid. Also contains evaluation of antiproliferative activity of NCI selected compounds, antiproliferative activity against MCF-7 cancer cell line, antibacterial activity and measuring the NO-releasing properties of the synthesized compounds. The fourth chapter includes experimental part of different methods used for preparation of the intermediates and final NO-donating coumarin-chalcone derivatives, the procedure used for the evaluation of the anticancer activity of NCI, MCF-7 cell line, in vitro antibacterial activity evaluation and measurement of the NO release.