الفهرس 
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Abstract
SUMMARY
Hematologic cancer is considered the most common and leading cause of cancer death for age group twenty and younger Hematological malignancies are classified basically into lymphoid and myeloid malignancies and each of which is subclassified into acute and chronic subtypes.
To evaluate the correlation between specific prognostic factors and hematologic malignancies help predicting the likely outcome of the illness. , the prognosis of hematologic malignancies was assessed and defined as good, intermediate, or poor according to a 3-yr survival probability of >50%, 20–50%, or <20%, respectively. Short-term prognosis is exclusively predicted by acute organ dysfunctions and by a pathogen’s aggressiveness.
For cancers like lymphoma, many factors determine outcome. Some are directly related to the disease - the disease stage, how large the disease is, or which organs are involved.
Other factors depend on the person involved - the age or sex of the individual, or his or her capacity to tolerate intensive treatment.
Outcomes are also dependant on the exact type of treatment received. Different treatments don’t lead to the same results.
Factors that predict for a better outcome are called ’good’ or ’favorable’ prognostic factors. Those that predict for worse outcomes are called ’poor’ prognostic factors.
The molecular characterization of tumors has a great impact on the newly designed targeted therapies and the prognosis of this malignancy. This was evident in discussion of AML and NHL. We also tried to enumerate the recent modalities of treatment of each subtypes concerning latest treatment. These lines of treatment include chemotherapy, the basic line of treatment up till now although the many side effects that may occur even on long run. Bone marrow transplantation has increasingly invaded the field of treatment especially after improvement of supportive care, methods of refining stem cells and regimens of conditioning therapies.
Targeted therapy is a general term that refers to a medication or drug that targets a specific pathway in the growth and development of a tumor. By attacking or blocking these important targets, the therapy helps to fight the tumor itself.