الفهرس 
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Abstract
The pr~~ent werk includ~d fouLty on~ cance~
patients with b~~tHri~l, funqal and vir~l infections,
and twelve apparently healthy l~dlvlduals a~ controls.
The varlatian~ in the total and ditferential
count5 were cb5erved. The mo~pholo9ical changes like
toxic gr~nYlatiQn, cytopla~mlc vacuolation, ae~rea5ed
nuclear lobulation, and OchlQ’S bodie~ ~re ev~lu~ted
as degenerative index. Three cytochemical ~taIn5
{perOXidase, neutrophil alkaline phosphacase and
nitrcblue tetr~zclium te5tl vera PQrformed to asses the
neutrophilic function tests in cancer ~cl@nts with
different types of infections.
The following results were obtalned:
!n canc~r patient5 with bacterlal infection,
le~kocytosis (in 40\ of ca~e5), absolute neutrophIlia
(in S5~ of cases) and lncreased degenerative index were
detected. Normal le~kocytic count was obs~rved in 60\
of ca~e~. Thl~ could be due to the mild a~ localized
type of infection or due to decreased n4tural
resistance encounteIed in our casas as a result of th~
pre-existing malignancy. Altern~tiv~iy the bone marrow 6Jreserves
might be exha~sted in these pa~ients~ so t~~t
they were unable to produce the expected brisk re5panse
encountered 10 normal subjects. Neutro~hilic functions
tests showed increased activity in malignant case& with
bacterial infection. Thu5. peroxidase, n.utra~hil
alkaline phosphatase and nitroblue tetrazalium
actlvttes were 51gnIElc~ntly Incre~sed·as compared to
those of normal controls.
In fungal (nfecte~ g~a~p, 50’ of ~ag~~ Bhowe~
severe leukopenia with abs~lute neutropenia,
lymphocytopenia and mon~cytopenia. TheIr neutrophilic
functIons tests showed c!creased activity. All the
cases with fungal infection had ~ematopoietc
~lignancieB 14 cases had acute leukemias and 6 cases
had non Hodgkin’3 lyuphoma). These findin~ might be
secondary to the presence of high incidence of fun9~1
infection In lmnunocoDproml~ed ho~t.
Tn virl infection, a significant decrease in
absolute neutrophilic count, and siqnitlc4nt incre~s~
in the absolute lym~hQcytic CQqnt ~nd d~gen&rative
in~ex. On the other han~, no signlflcant chanq~~ we~~
~etected in total leUkocytIc count, neutrophil alkalin~
pho~phat8~e, peroxida8e and I~ducti~n by nltroblue
tetrazollum. In th@ present ~tudy, the correlation between
absolute neutrophilic count and neutrophilic function
test was studied. !t waS noticeo t~at pezoKid~~e ~t~ln
could be cQn5ide~ed as the mQ~t sensitive Indicato~ for
various tYQe~ of Infectiorr~ In no~ leu~emic cancer
patients.