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العنوان
Endocrinological studies in acute liver diseases(thyroid function in viral hepatitis)/
الناشر
Mohamed Abbas Arafat
المؤلف
.Arafat,Mohamed Abbas
هيئة الاعداد
باحث / mohamed abbas arafat
مشرف / Mohammed Osman
مناقش / Mohammed Ahmed Mostafa
مناقش / Mohammed Osman
الموضوع
internal medicine
تاريخ النشر
1979 .
عدد الصفحات
100p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/1979
مكان الإجازة
جامعة بنها - كلية طب بشري - باطنة
الفهرس
Only 14 pages are availabe for public view

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from 119

Abstract

A t _Bri.o.~cr.hemical deter~mi~atiott_s:The mean velu6 ± SE for the seru’i1concentration
of each of totel protein, albumin, glo~ulin are presented
in table 2. The last coulmn of the table
represents the ut” velue obtained from the comparison
of the mean ve.Lue of the two groups using umpaired
tiT”test of significance. The serum level of each

of tote.lprotein and albumin of the vf.r-aL hepatitis
~.oup was lower than that of the control grOtl]?_
However, the difference between the t1ro mean values
was significant only for albumih (p ~Ol)~
• Globulin, on the other hand, had the B~me concent
ration in the two gro upa,
2. i___erur’ m__ Br..•i_• l•.••i•~r~_ub••i••~n ( Tote•• l and direct _)
The mean valile± SE for each of serum totsl
and direct bilirubin for both the control end viral
hepatitis grollp are presented in te1:>le~. The serum
level of each of botrxL and direct bilirllbin ”1E!.S
z-emr-r-kab Ly .\ligherin the viral hepatitis than the
control grollp. The magnd t ude of increese was ).475
fig% ( 695 % ) and ).190 fig% ( 159 % )for the total
and direct bilirubin, respectively. Urrprd.r-ed ”T” test
of significance showed that the difference bet’~en the
tvrogrollps in e2ch peremeter is statistically
TABLE (4) • Hean Values and standard errors of serum Levels of
total protein • albumin • g10bulin and Creatinine
in control and Viral hepatitis graups.
Parameter Control group
( Ne 23 )
Viral hepatitis
group
(r’e20)
,,~”
value
Total protein • g % 7.2~ 0.15 6.98 ! 0.19 1.093Aibumin • g )(, l:.84;!: 0,16 3.99! 0.15 3.909
Globulin , g (,t, 2.99;!:o.ri 2.99; 0.20 0.000
Crea.tinine • mg If, 0.911!0.04 1.06+ 0.06 1.818
** » L: .01
TABLE (J). Mean values and standard errors of
serum levels of total and direct
bilirubin in control and viral hepatitis
groups.
Control
group
(N:=23)
Viral hepatitis ”t”
group
(N=2G)
p
Direct bilirubin.ng~ 0.2CtO.045
signifieent ( p <.01 ), table 3.
The serum creatinine concentration fOr the control
and viral ~epatitis groups is nresented in table Z as
x :!:. SE. The difference between tl-Je t”IO grouPR ”’I’lli’!
statisticnlly insignificnnt.T..t_.S’GPT~.and._aa~l~ali..n~.e•__
The mor-nvr.Lue + SE for the Rerum 10’11’)1of 08C11. of
SGOT,SGPTarid r.Lkr.Lfne n1J.osnh8t8s8 n:r-enresenttod in
noted in the vLr-r.Lhenpti tis gJ”OllT8JS cOl11n’”1retdo the
normrL cont r-oL ,’!roup. For e[1c1:1enz’>’111thOe oi·8ference
bet’.7oen t.1-:1emern voLues of the tyro r~rO!lns”’8R
8trtidicoll” si”ulific”nt ( P i( .(’1 ).
B. H--o_r-•m...•_on-a-_l, ._-P-E-7_S8,’t.r.•_-:
The moon vo.Lue + SE for 02C’1 of sera”, t”t”l th”,:ro:d.ne
ratio for hot’) the control 8’1d virpl”en,-,ti tis gronD
nrc presented in tnhIe 5 and p’rfl’1h.ic,-111,i11ust-r”ted
in figures I and 2. Unnrd.r-od ”Til test ’’’’’’1’’ ’”1.’1nlied
to the dCl-tr to test tbe sig’1.ific~moe of il:i.ffe-ren~e
be tween the t’.eromoon vrLue s of er.ch nnr8meter and
the r-esu l t s of” 8:1Chf’l1rli”sis nre ShOFn1in the IrEt
cou’lumn of the t”bl0 ”’8 ”Til vr Lucs ;
- 70 -
T~BLE (~) Mean values and standard errors of
s~rum levels of SGOT, SGPT and alkaline
phosph~tase in control and
viral hepatitis groups.
Para’ilenter
Control
group
(N - 23)
Viral hepatitis ”t”
group value
(N - 20)
soor ,
wrobleT”J’skiunits
10.151:0.46
SGPI’,
wroblewski units
lO.65:t0•69 137.50+20.60 6.459**
Alkaline phospha- 10.(4+0.80
tase, kind and king units
** P £. .01
-------------~-- ---- ---
- 71 -
THBJ”E(5.);’leanva1ues and standord errors 0:1: Serum total
thyroxine and normalized th~~ine ratio in
control and virll hepatitis groups.
Control ., Virll hepatitis ,.,t,,.
Parameter group group value
( iv •• 23 ) ( N •• 20 )
Total thyroxine J 10. 40 + 0.86
NTH 1.020.- 0.012 1.978
<r t: .01
72
TOTAL THYROXINE
N (J) co o
•1...1..• (
Q
--”
:t> (j)
Z rTJ :.:0
0 .c;z i- I<....-. ---1 I :xl 0 J> -j I r J>
r !
I
Ii rTl ---1
\J T
J> -c
•-..-...I• JJ ---1 0_. X•.....•
(J) -7 .”-
rTi
CI
::0 •.....•
Z 0~
-L0. n0 (J) _.,
L_
---1
:JJ
0r
.=~~--m~l •.m.•.m:m~~:!,•;!•:!!!!:!!·!!!!.!~!!!!!!!!!!!!’l1r!!:r:!!’!re:!’!!!!~rnm:~ ••r..r•.•.~~.r..r..~.J iii::::: :~::~::::: :::::::::ii :::::: i::Uli::: :::::~:~: :~::::1~:: ·•:••.·•·•.·:.·.·:::5::::55 I:::::::::
•••••••••••••••• ••••u ••~.... ·.·.·.Iiiiiiiilf---l ::~::::: :u::••:•:•::~:••:.= II:::::::::::::::::::: :::~:::::::: •••...••• :~::~:::::::::::I::::::~::::::::::::::::::::::::::II:~:::::::::::::::: II:::::::::::::::::: :::::::: :::55::::: I:::::::I:::::::: I:::::::::
.<
I
->
N
noZ
-I
::0
or
- 75 -
errors for t’l€ two groups were very close.
The coefficients of vrcrie:rlce for the -:’<TRwere 5.64
and 6.38 % for t:’le control and viral ’1.epetitis groups,
respectively.
--”----
--”---
- 76 -
c. The relationship between each parameter of blood analysis
and thyroid function parameters in viral hep8titis
pa.tients.
The relationship between each of serLUIItotF’l
protein, albumin, globUlin, SGOT& SGPTand each of
T4 and JTTR was tested by Peor-son nroduct moment correlstiO!
l eoefficient • Sa!i’Jl1?rVof this nnal \Tsis is nresented
in table 6. The only significpnt 0ifference
obtained ”ms between SG,)Tand tot?l T4 (p <.(5). This
significpnt COrre Lrt Lon was nosi ti ve indic ~ting thpt
with the increase in serum level of SGOT, there was a
cC’rres))ondin::c increpse in T4. The 1Jrediction eqLll”tion
for such a relptionship was found to he:
y = 7.80,0 + 0.016 x
(Serlrn thyroxine) (SGOT)
It should be noted thpt there ”’?S [) tendency for
positive cor)~elptions ’)etween SGO’” & 1’TR. and SGPT
& T4, I’llthOUgh the obt eLned ”r”s did not r-e ach t’le
statistical significaIlce.
-77-
Table (6). Correlntion Coefficient (r) between blood
c,;lnlysis p2,rometers and thyroid function
pnrnneters indices in vir2~ hepntitis
UrI!Vnlue
DnrC::lster T4 J’’TR Totnl protein - 0.190 - 0.08)
Albunin - 0.023 - 0.060
Globulin - 0.196 - 0.0)6
SGOT 0.468 )( 0.)42
SGPT 0.415 0.011