الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
In the present work. we studied the effect of the
high-ceiling diuretics on serum uric acid in patients
with oedema due to different causes.
Fu~osemide was used as an example of the high-ceiling
diuretics and the study was carried out on 45 patients
with oedema. Those patients were classified into three
groups. each of 15 patients. The first group comprised
patients with oedema due to liver cirrhosis. the second
group comprised patients with renal oedema. and the third
group comprised patients with oedema due to congestive
heart failure. 15 norma L individuals 0 f the same age range
and sex were taken a~, a control group.
Furosemide is structurally related to the thiazides.
but its principle site of action is in the ascending limb
of the loop of Henle. It probably also has effects along
the entire nephron with the exception of the distal aldosterone
sensitive portion.
Furosemide is efficient in the presence 0 f glomerular
filtration rates of 10 ml/minute or less as in severe heart
failure and renal failure where other diuretics fail.
The patients and the control group were given two
tablets of furosemide i.e 80 mg for one week and serum
uric acid was estimated before and after receiving
furo sem ide.
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Serum uric acid may be raised because of a diminished
tubular secretion of uric acid. an increased endogenous
production of uric acid or a high protein intake.
___ The first group of patients with liver cirrhosis
showed a highly significant increase in the serum uric
acid compared to the control cases before receiving
furosemide .
After receiving furosemide. there was a significant
increase of serum uric acid in these hepatic cases compared
to the level before furosemide.
The second group involving patients with renal failure
showed a highly significant increase in serum uric acid
compared with control cases before furosemide. After furosemide
in that group of patients with renal disease. a highly
significant increase in serum uric acid level was observed
compared to control cases after furosemide.
In the last group which included patients with congestive
heart failure. an insignificant increase of serum uric
acid level before furosemide was observed compared to its
level in the control q roup , A highly significant increase
in the serum uric acid was observed after receiving furosemide
in comparison to the control group after furosemide.
It is thus concluded that ingestion of many diuretics
particularly furosemide. causes a rise of serum uric acid.
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It is thus important in ~atients receiving diuretics
especially furosemide, to observe their serum uric acid
sO as to protect them against the hyperuricemic effect
of these drugs.