الفهرس 
Material and methodsOnly 14 pages are availabe for public view
 |  | from | 112 |  |  |
| | | from | 112 | | |
Abstract
The epithelial d group antigens are glycoprotein
or glyco-lipid complexes. Their antigenicity
is derived from their oly-saccharide side chain which
is synthesised as a wise elongation under the
control of glycosyl ferase enzymes. They are present
in all body tissues the Central Nervous System
78% of the human show blood group antigen
activity in all their s cretions and body fluids except
the Cerebro Spinal Fluid nd they are known as secretors.
The blood group are lost early during
the process of malign transformation in different
organs. This study of epithelial blood group antigens
in different laryngeal lesions included 50 cases of
differ~nt pathological lesions and. it proved that,
the blood group antig ns are not affected in benign
lesions and low grade dysplasia of the larynx. But,
they are affected in potentially malignant lesions
e.g recurrent papilloma and high grade dysplasia. This
study proved the exist~ ce of a direct relation between
the behaviour of the malignant tumour and its grade
on one hand and the loss of the isoantigens on the
other hand. Thus, the epithelial blood group antigens
may help to detect ea ly malignant change in benign
lesions while they are still at a high curable rate.
TheYlllay also 1.lelp :t.o assess the tumour aggressiveness
and may be of a good ~ro nostie value.
52