![]() | Only 14 pages are availabe for public view |
Abstract DEFINITION Chronic heparitiJl designatt$ a group or disol’dcrs characterize<l: by an unr lVed inl1!11ltmatory disease oCtile ’iveT that ~ existed for mare tJtan. six months (B yet ju., eta! 1976 ). The eriteri”, that are lIeceptcd mO$twidely for cla.ssiikalion 0 ollie hepatilis •.•e••re developed in 1968 and divide chronic hepa~tis into tw broad categories hued on histologic cba:nge$: ,chronic persistent and chronic active ·tis ( De OA;lOt~j. eta! t 968 ). This origiDal system ofclassili.catioill has subscquety heM reviewed and refined . (Bianchi L., et aI., ~971 )_SubsequellUo the initial classifcatioli. thecae gol)’ of obrooic lobular hepatitis W~ added. ChroDi4> Peqi:stant hepititis (epN): It ;9 chara.ctcti~d hUtologieally by portal lntlllDlJ[Ultion and is b’ Iy • lion progressive process, Chroole lobular bepatitis (CLH): It is characterised by focal lIfGS· of necrosis 81: iIIf\~mm.ation tbrou’ out lb¢ hepatic lobule witll minimal portal &; periportal. inflammation (Yiaw Y-F, e1 al, 1982). CbroDic aerive hepatitis: It is characterized by histologic evidence of hepaloc-eUular necrosis &: fib osis and is eonsidred a progerss.ive pre-cirrhotio process ( de ~oole J, 111.]968)0 T:lle availability of perl;:l,ltaneous liver biopsies from patients with cI ical and laboratory evidence of hepatic ilillammatiott led to the ~tion(l hepatic inflammation types. and imponance of cltrollic hepatitis. The develo t of aminotransferase tests as ~iable indicah’lfS of hpatic Wlanunation assisted ’ eatly in allowiog recognition of chronic hepltitis in patleftts whQ eitller were lLS)’tI\pt matic or had or:ilyltliAimal evidence of liver inj”Ul)’. The use of SllqueBtial dete - of aminotr~lIufc.ras.e level made itpowDle to follow the course of Ii er disease 0 er time. The discovery in L967 ·of lhe AllStrdia antigen ( HBsAg)was full wed by remarloWle advances in the undentllllding of hepatitis B-induced liVef di ase that allowed identification of the largesubgmup of patients with chronic hepatit” B·lt Ms been established that 2 to 10 pm:etrt of adult patients with acute hepaUli B do not completely recover- and that mall)’ of these pIlIieIlts develop chromc h.epatitis Redeker AG 1915). |