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Abstract Our study had been carried on 20 hypertensive patients with chronic renal failure and on 10 hypercalcaemic patients with chronic renal failure. Our cases were selected from the out-patient clinic and in-patient section in Mansoura. General. Hospital. The following finding were reported in this work : 1. 33% of the hypertensive patients were hypercalcaemic. 2. 33% of the hypercalcaemic patients were hypertensive. 3. A significant DROP of both systolic and diastolic blood pressure was observed on the 12 th day after stoppage of Vito D. the mean serum calcium on the 12th day was 10.97 + 1.04 • .On ’the 3rd, 6th and 9th day after stoppage of vito P. when the mean serum calcium was still above the normal range, no significant DROP of blood pressure occuredQ On compa~ing the mean blood pressure - 80 - on 12th and 24th day, no statistically significant DROP of blood pressure was found. The rapid DROP of blood pressure makes us believe and directs our attention to the following mechanisms as being responsible for the hypertension in hypercalcaemic patients. Increasing the vascular resistance. Increasing in the cardiac output. Increasing in the plasma renin activity. Renal damage resulting from hypercalcaemia is not probably the mechanism by which hypercalcaemia can cause hypertension that is because the rapid DROP of, the blood pressure will not occure if renal damage is the underlying cause. On the light of this study we advice chronic -renal failure patients with hypertension who take Vito D and hypercalcaemic,to stop Vito D leading to DROP the blood pressure to the normal rangeo |