الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
SUMMARY
In many skin diseases histopathological examination is an essential method for diagnosis, yet it is time consuming and troublesome to the patient. Cytodiagnosis
is a rapid, easy and less troublesome method of inves-tigation in dermatology.
The aim of the present work is to test the diagnostic reliability of cytologic examination and to judge to
what extent it can be used as a diagnostic method in vesicular including allergic skin response and neoplastic skin diseases.’
One hundred and fifty cases of vesicular, allergic skin response and neoplastic skin diseases were examined clinically and cytologically. 118 of them were biopsied and examined histopathologically and the diagnosis compared with the clinical and cytological ones, while the remaining 32 cases were diagnosed on the clinical and cytological grounds only.
Out of the 150 cases, 381 cytologic smears were collected by differeht cytologic techniques. Thus 83 smears were collected by direct smear technique, 179 by
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scraping Smear technique, 98 by imprint smear technique and 21 by aspiration smear technique.
The cytologic smears from all the cases were stained by Papanicoulaou’s stain, 50 smears stained by Giemsa stain,
3 smears stain by Fontana stain for detection of melanin, and 2 smears by Hematox. and Eosin stain.
A paraffin sections were prepared from the biopsied material and stained by Hematox.and Eosin and 2 sections from melanoma were stained by’Fontana stain.
The 150 cases were classified into two major groups:
Group I. Vesicular including allergic skin response lesions (50 cases).
Group II. Neoplastic skin disease including benign
lesions (17 cases) and malignant ltsions (83 cases).
Group I. Vesicular skin diseases:
Fifty cases of vesicular diseases including allergic skin response lesions were examined clinically, cytologically and 18 cases from them were examined histopathologically. The cases
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found were one case of subcorneal pustular dermatosis, 5 cases of bullous impetigo, 8 cases of primary acute
contact dermatitis, 4 cases of allergic contact dermatitis, 2 cases of subacute contact dermatitis, 6 cases of herpes simplex, 3 cases of herpes zoster, 9 cases of varicella,
8 cases of pemphigus vulgaris, 3 cases of dermatitis herpetiformis and one case of erythema multiformis.
In interpretation of the smears typing of the nature of the lesions was possible in all cases and this is particulary true when the cytologic findings were correlated with the clinical feature of the diseases. The clinical and cytological diagnosis were confirmed by the histopathological one. Group II. Neoplastic skin diseases: A. Benign neoplastic skin diseases:
Seventeen cases of benign neoplastic skin lesions were examined clinically, cytologically and histopathologically.
Zn interpretation of smears a negative results for malignancy were obtained in 16 cases (94%), in 5 (31%) of them a definite cytologic diagnosis of
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the disease type was made as 5 cases of sebaceous adenoma and confirmed by the histopathologic diagnosis. In the remaining 11 cases (69%) the definite diagnosis could be made only when the cytological findings were correlated with the clinical one, and they diagnosed as 5 cases of seborrhoeic keratosis, 2 cases of kerato-
acanthoma. 3 cases of pyogenic granuloma and one case of fibroangioma. The histopathological diagnosis confirmed the clinico-cytological one.
In one case (6%) the cytologic examination yielded suspecious result for malignancy, but the histopathologic examination yielded benign lesions of keratoacahthoma
in proliferative stage. B. Malignant neoplastic skin .disease:
Eighty three cases of malignant neoplastic lesions were examined clinically, cytologically and histo-pathologically.
In interpretation of smears a positive result fbr malignancy was made in 78 cases (94%), from which 74 (94.9%) the definite cytologic diagnosis of the lesions types was made as 21 cases of basal cell carcinoma,
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29 cases of squamous cell carcinoma, one case of baso-squamous cell carcinoma, 5 cases of anaplastic carcinoma
2 cases of melanoma, 5 cases of metastatic adenocarcinoma
from the colon (g.I.T.), one case of metastatic or
extention of intraduct carcinoma from the breast, 2 cases
of metastatic infiltrating duct carcinoma from the breast and 8 cases of metastatic undifferentiated
carcinoma. These cytologic diagnosis were confirmed by the histopathologic one. Four cases (5.1%) only diagnosed
as malignant lesions but the exact type of malignancy could not be determined cytologically but histologically the
’ definite diagnosis were one case of basal cell carcinoma, 2 cases of carcinoma in situ (Bowen’s disease) and one case of metastatic infiltrating duct carcinoma from the breast.
Five cases (6%) were diagnosed as suspicious for malignancy, and by histopathological examination the exact malignant type of the lesions could be determined as 2 cases of
basal cell carcinoma and 3 cases of squamous cell
carcinoma.