الفهرس | Only 14 pages are availabe for public view |
Abstract The present study focused on applying tissue engineering to the science of endodontics. Tissue engineering and regenerative medicine are emerging fields that have only just recently found their way into the dental field. With the expanding pressure on health care professionals to provide more superior treatment options, it has become mandatory to explore new territories. It is no longer acceptable to provide a treatment option that will not simulate the natural as closely as possible. It is from this belief, that the return to the basic sciences and the building blocks of the human body has been reincarnated. The objective of the present study was to evaluate the ability of tissue engineering to regenerate normal healthy dentin/pulp tissue in ex-vivo sites, when transplanting cell/scaffold constructs subcutaneously in the dorsal surface in the rabbit model. Materials & Methods: Biodegradable synthetic 50/50 poly (lactic-co-glycolic acid) scaffolds were fabricated using the solvent casting/particulate leaching technique to form scaffolds with different groups of porosity. Four groups of scaffolds were designed, group 1(0.7 gm salt of particle size 150-180iim), group II (0.7 gm salt of particle size I 80-300im), group III (0.9 gm salt of particle size 150-18011m), and group IV (0.9 gm salt of particle size l80-300im), in search for the optimum porosity characteristics of a scaffold for use in dental tissue engineering. |