الفهرس 
Inflammatory Response to Percutaneous Coronary InterventionOnly 14 pages are availabe for public view
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Abstract
Introduction: Many clinical studies have evaluated the inflammatory response (mainly interleukin [IL]-6 and C-reactive protein [CRP]) after percutaneous coronary intervention (PCI) in patients with coronary artery disease (CAD). This work aimed to verify the source of possible elevation of IL-6 and CRP after PCI using coronary sinus sampling. Subjects and Methods: We studied 87 subjects who underwent coronary angiography for diagnostic, therapeutic, or follow-up purposes. Blood samples were taken during the catheterization study from the coronary sinus. Coronary IL-6 levels measured by ELISA, and high-sensitivity CRP levels were measured by immunonephelometry. The subjects were then classified according to their coronary angiographic findings into non-CAD (no evidence of significant organic CAD), mild CAD (1 vessel narrowed), and severe CAD ≥ 2 vessels narrowed) groups. PCI (including stent deployment) was performed in 16 CAD patients. Results: mean coronary IL-6 value was higher in the severe than in the mild CAD group (3.67 ± 2.48 vs 2.3 ± 1.15 pg/ml, p = 0.027). The mean coronary IL-6 value was higher in the subjects who underwent PCI than in those who did not (2.9 ± 1.23 vs 1.87 ± 0.9 pg/ml, p = 0.037), and the same was found regarding CRP (1.244 ± 0.72 vs 0.498 ± 0.15 mg/L, p = 0.032). Coronary IL-6 values correlated positively with the coronary CRP values (r = 0.374, p = 0.017). Conclusion: the increase in coronary IL-6 and CRP levels after PCI in CAD patients may be attributed to their release from coronary atheroma secondary to direct mechanical effect applied on the atheroma by balloon inflation and stent deployment.