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Abstract Capillaria species parasitize many classes of vertebrates, although only four species have been found in humans, namely C. philippinensis, C. hepatica, C. aerophila, and C. plica. Capillaria philippinensis which causes intestinal capillariasis can be one of the most virulent helminthic pathogens of humans, with extremely high mortality rates. Parasite virulence can be largely ascribed to the ability of the worm to cause hyperinfection. Common clinical symptoms in intestinal capillariasis are chronic watery diarrhea, malabsorption, and wasting. Definitive diagnosis of intestinal capillariasis is made by identifying eggs or adults in stools. Immunodiagnostic tests, biopsy specimens and endoscopy play a supplementary role to the parasitological diagnosis. The eggs of C. philippinensis are excreted sporadically in feces that lead to delayed diagnosis of intestinal capillariasis. Therefore, multiple stool samples may be important to early diagnosis in some cases. An inexperienced laboratory worker may confuse the eggs of C. philipinensis with those of Trichuris trichiura. A history of raw freshwater fish consumption is an important clue to diagnosing C. philippinensis infection. Delayed and incorrect diagnoses are common with C. philippinensis infection, leading to delays in treatment and clinical suffering, so to eliminate C. philippinensis infection, early diagnosis is necessary by improving the experience of laboratory workers, using ELISA as a screening test for human intestinal capillariasis in endemic areas whose coproscopy is negative for worm eggs, larvae or adults and health education to promote the consumption of cooked fish and to avoid defecation into a water resource. |