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العنوان
Mechanisms of microbial resistance to antimicrobial agents :
المؤلف
Younis, Faten Abd El Fatah Mohamed.
هيئة الاعداد
باحث / فاتن عبدالفتاح محمد يونس
مشرف / إقبال محمد أبوهاشم
مشرف / وفاء محمد الإمشاطي
مناقش / ثريا السيد بدوى
مناقش / نوال عبدالجليل غريب
الموضوع
Drug Resistance, Microbial-- physiology.
تاريخ النشر
2010.
عدد الصفحات
118 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة المنصورة - كلية الطب - الباثولوجية الاكلنيكية
الفهرس
Only 14 pages are availabe for public view

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Abstract

The treatment of bacterial infections is increasingly complicated by the ability of bacteria to develop resistance to antimicrobial agents. Antimicrobial agents are often categorized according to their principal mechanism of action. Mechanisms include interference with cell wall synthesis (e.g., -lactams and glycopeptide agents), inhibition of protein synthesis (macrolides and tetracyclines), interference with nucleic acid synthesis (fluoroquinolones and rifampin), inhibition of a metabolic pathway (trimethoprim-sulfamethoxazole), and disruption of bacterial membrane structure (polymyxins and daptomycin). Bacteria may be intrinsically resistant to more than one class of antimicrobial agents, or may acquire resistance by de novo mutation or via the acquisition of resistance genes from other organisms. Acquired resistance genes may enable a bacterium to produce enzymes that destroy the antibacterial drug, to express efflux systems that prevent the drug from reaching its intracellular target, to modify the drug’s target site, or to produce an alternative metabolic pathway that bypasses the action of the drug. Acquisition of new genetic material(mobile genetic elements) by antimicrobial-susceptible bacteria from resistant strains of bacteria may occur through conjugation, transformation, or transduction, with transposons often facilitating the incorporation of the multiple resistance genes into the host’s genome or plasmids.