الفهرس 
Introduction
Chemotherapeutic agentsOnly 14 pages are availabe for public view
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Abstract
ANC and Vid were labeled by the same technique with % labeling yield about 90 %. 125I-ANC and 125I-Vid were distributed rapidly in normal mice to different tissues, especially those of high proliferation rate such as stomach and excreted rapidly in urine. Biodistribution of 125I-ANC and 125I-Vid in tumor bearing mice showed increase in the uptake of radioactivity in tumor site. Both DEX and LMS produced significant increase in the uptake of 125I-ANC and 125I-Vid in tumor sites and significant decrease in most other tissues. 125I-ANC or 125I-Vid produced toxic effect to Ehrlich cells and this effect increased with the increase in radioactivity and of incubation time.Locoregional administration of 125I-ANC or 125I-Vid daily for 15 days starting at the 3rd day of inoculation showed significant decrease in the size of solid tumor. Either DEX or LMS produced significant decrease in size of solid tumor when combined with 125I-ANC or 125I-Vid, especially when mice pretreated with them, 10 days before inoculation. locoregional daily administration of 125I-ANC or 125I-Vid starting at the 3rd day of inoculation were required to obtain maximum % survival in EAC bearing mice.