الفهرس | Only 14 pages are availabe for public view |
Abstract Cisplatin is a highly effective chemotherapeutic agent used in the treatment of a wide variety of cancers.gentamicin is one of the most important aminoglycoside antibiotics used against serious gram-negative ingections.however,the majour complication of cisplatin or gentamicin treatment is nephrotoxicity that limited their clinical use.in the present study,the effect of natural compounds such as ginkgo biloba or L-carnnitine was evaluated against nephrotoxicity that was induced chemically in experimental rats by cisplatin or gentamicin. This study was conducted to evaluate the Tatherbed natural compounds such as Djincubeluba well - Carenetin against renal toxicity updated experimentally both cisplatin or gentamicin on rats. So were the events of poisoning renal injected cisplatin (6 mg / kg ) as a single dose in the abdomen and we have to make sure of the occurrence of such by setting the kidney functions that involve measuring the level of Riyatanin and urea in the blood as well as the rate of extraction renal creatinine and measuring total protein director in the urine On the other hand has been the study of isolated bladder rings response to acetylcholine Proving Varmakologih , and also by measuring several vital signs in kidney tissue , such as : - Oxidized lipids . Activity enzyme super oxide Mismiotiz the Kidney content of glutathione reductase . Tech also portray kidney Balmikrscop to a questionnaire ah effects of indestructibility . The results of this study that cisplatin may latest failure been inferred functionally as the level of creatinine and urea in the blood and protein in the urine rose significantly while the rate of extraction renal creatinine decreased substantially in the fifth day of giving cisplatin , has also been inferred Pharmacology of Halal shortage acute weight in rats and a marked increase in smooth muscle constriction of the urinary bladder rings under the influence of acetylcholine . As the latest medication statistically significant increase in the level of oxidized fat and a lack of glutathione reductase activity enzyme super oxide Desmiotiz the kidney in a sign Biochemical reflect the extent of renal toxicity. |