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العنوان
Synthesis and characterization of certain five-membered heterocyclic compounds as schistosomicidal agents /
المؤلف
El-Emam, Ali Abdel-Rahman.
هيئة الاعداد
باحث / على عبدالرحمن الامام
مشرف / ع. أبو العوف
مشرف / م. الكرداوى
مناقش / ع. أبو العوف
الموضوع
Heterocyclic compounds. Sulphur. pharmaceutical chemistry.
تاريخ النشر
1980.
عدد الصفحات
135 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
01/01/1980
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - Department of pharmaceutical chemistry
الفهرس
Only 14 pages are availabe for public view

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from 153

Abstract

Many aryl homocyclic and heterocyclic basic compounds are well known as nonantimonial schistosomicide! agents. Thiaxanthone derivatives, benzothiopyrano indazoles, niri-dazole and other analogues are potent antibilharzial agents. These compounds are characterized by essential features contributing the activity, i- the presence of a heterocyclic nucleus containing a sulphur atom, ii- the presence of a dinitrogenous moiety embedded in the whole molecule,iii- the presence of some groups or radicals which enhance the acti¬vity and modify the duration of the compound.Based on these prerequisites, certain series of comp¬ounds were designed and prepared herewith, containing thiophene or furan nucleus attached to a 2-pyrazoline or 2-pyridone ring.Returning back to the previous series of Schiff,s bases derived from N-(benzylidene or cinnamylidene)-l-naphthyl-amines which proved to possess great schistosomicide! acti¬vity, the synthesis of new series of Schiff’s bases was presented in this work, derived from the newly synthesized pyrazolines.