الفهرس 
Introduction
Preparation methodsOnly 14 pages are availabe for public view
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Abstract
This thesis aimed to synthesize new derivatives with known biological activity such as thiadiazole, oxadiazole, triazole, thiazole and thiadiazolidinone which linked with quinoline moiety leading to increasing the anticipated biological activity of these newly compounds. Quinoline2 carbohydrazide reacted with different isothiocyanates to give the corresponding thiourea derivatives which underwent reaction with different reagents e.g., NaOH, POCl3, HgO, BrCH2CO2C2H5, ClCH2COCH3,....etc. Furthermore, the hydrazide reacted with KSCN affording corresponding thiosemicarbazide which reacted with POCl3, HgO giving aminothiadiazole, oxadiazole derivatives respectively .DMF dimethyl acetal reacted with the hydrazide yielding Schiff base which underwent with different amino derivatives via transamination reactions forming new amino compounds. The biological behavior of some of these compounds as antibiotics had been done also, testing some of them as preservatives in leather manufacture processing.