الفهرس 
AbbreviationsOnly 14 pages are availabe for public view
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Abstract
Background: During the past two decades, there has been considerable progress in the treatment of childhood leukemia. Most children with ALL may now be cured with current therapeutic regimens,the ability to distinguish good risk patients from those who are likely to relapse has important clinical implications.. Aim of work: This work aims at the detection of submicroscopic leukemia which remain below the threshold of morphologic methods and may escape the spectrum of conventional methods of assesment of remission. This will include the assessment of DNA ploidy and S phase % of the mononuclear cells of the peripheral blood and CSF of patients with acute leukemias at the beginig of treatment and after induction chemotherapy by using flowcytometry. Methods: 1. History and thorough examination 2. FAB classification of BM aspirate 3. Flowcytometric study of peripheral blood for DNA ploidy and S- phase%. 4. Flow cytometric study of CSF for DNA ploidy and S- phase%. Results: In our study, all flowcytometric data showed a reduction after induction chemotherapy and that reduction was marked and we related that reduction to the prognposis. Conclusion: Study of minimal residual disease of childhood acute leukemia using flowcytometry including the peripheral blood and CSF