الفهرس | Only 14 pages are availabe for public view |
Abstract Glycosylated Hb is a model of non enzymatic post-synthetic protein modification proportionate with blood glucose level. Its role in uremia is however unclear. Moreover, the effect of uremia on Hb glycosylation was shown to be more complicated. Therefore, the aim of this study was to clarify the reflection of uremia on glycosylated Hb level. The material of this study included 30 patients with CRF and CRF diabetics besides 5 non uremic diabetics and 10 healthy controls. Glycosylated Hb was assayed in all subjects and was reported after in uremic cases. We concluded that the level of glycosylated Hb has been significantly reduced in CRF which could be due to shortened red cell survival, while in CRF diabetics it was higher due to their high blood glucose. Moreover, hemodialysis resulted in elevation of glycosylated Hb due to the improved red cells survival. A positive correlation has been revealed between glycosylated lib and serum creatinine, a finding that may aid in the diagnosis and follow up of CRF particularly in doubtful cases. |