الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer in men, the seventh most common in women and the third leading cause of cancer-related deaths worldwide (1,2). HCC accounts for approximately 85% of liver cancers (1)and is characterized by a highly heterogenetic pathogenesis with an aggressive clinical course leading to poor survival. The risk factors for HCC are relatively well defined compared with those for other cancers. The risk factors include chronic hepatitis B virus (HBV), hepatitis C virus (HCV) infection, chronically heavy alcohol consumption, aflatoxin B1 (AFB1) exposure and nonalcoholic fatty liver disease (NAFLD) (2). The incidence of HCC is considered to be significantly <higher in eastern Asia and sub-Saharan Africa, which are endemic areas of HBV infection, but the incidence of HCC is rising in Western countries due to increases in HCV infection, chronic alcoholic intake and NAFLD (3, 4).As of late, there is an increasing interest for discovering natural antioxidants from plant materials to replace manufactured ones. Natural product can be used in traditional or modern medicine or as starting points for drug discovery (5). Natural product is phyto-secondary metabolites that have essential biological and pharmacological activities, such as; anti-allergic, anti-biotic, anti-carcinogenic (6), anti-oxidant, anti-inflammatory, anti-hepatotoxic, anti-tumor and anti-microbial effects (7). Phyto-chemical compounds have been proved to have an anti-oxidant activity such as; phenolic acids, flavonoids, alkaloids and sulphated polysaccharides.