الفهرس 
Chapter 1: IntroductionOnly 14 pages are availabe for public view
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Abstract
The skin serves as a barrier against the external environment
and is the outer layer of the body. In this line, chronic wounds are a
risk factor for skin cancer development and severe skin injury may
be fatal, hence finding an adequate dressing for wound healing is
highly warranted. Cryogels are three-dimensional porous spongelike structures. They are attracting great attention because of their
exceptional features i.e., extremely porous structure, high surface
area, high mechanical strength, flexibility, biocompatibility, and low
density. Such properties make cryogels convenient for many
biomedical applications, such as drug delivery, and wound dressing.
Thus, chalcone derivative loaded cryogels was developed by freeze
drying technique. The physical properties of the formed cryogels
were evaluated using SEM, FTIR, TGA, BET, and swelling. The
result of characterization confirmed the successful integration and
interaction of chalcone moieties with chitosan cryogel forming
porous, interconnected structure that is favourable to facilitate the
healing process.
Aim of the work:
1. Synthesis of a new altered chalcone conjugated with
phenothiazine
2. Preparation of three-dimensional porous sponge-like structures
(cryogels) loaded with the altered chalcone
3. Development of a proper wound dressing that prevents
microbial infection, improves cell migration, enhance
Summary
2
angiogenesis and tissue remodelling and at the same time
nontoxic.
4. Assessing the prepared cryogel as possible local drug therapy
system to deliver anticancer agent to skin cancer.
Keywords: Cryogel; Chitosan: Chalcone; Squamous skin cancer;
wound healing; Antimicrobial.