الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Genital warts are considered a frequent form of STDs, which are caused by HPV infection. They are highly stigmatized, negatively impacting the quality of life of patients worldwide. The current main therapeutic options for warts include the destruction of visible lesions by physical or chemical methods and immunomodulating therapies. Nevertheless, aside from the usual risk of recurrence, none of these modalities are regarded as the gold standard because the cost, side effect profiles, dose schedules, length of treatment, and overall effectiveness of these therapeutic techniques differ significantly. Topical, intralesional and systemic immunotherapeutic methods have recently attracted more attention in the treatment of warts because of their non-destructive action, good safety profile, promising results, suitability for pediatric patients, and low recurrence rate. Furthermore, patients with numerous warts find them more convenient, especially if they are connected to effect on distant lesions. One of the immunotherapeutic strategies that has been demonstrated to be successful in the treatment of many types of warts is intralesional immunotherapy, which makes use of a range of antigens and vaccines, including Candida albicans antigen. This immunotherapeutic approach is mostly reliant on the host’s immune system, CMI, which inhibits the growth of warts by generating Th1 cytokines such as IFN‐γ, which trigger NK and cytotoxic cells, ultimately eliminating HPV infection. Candida albicans antigen immunotherapy seems to be a promising treatment option in patients with whom the warts are either resistant or not amenable to destructive modes of treatment. Cryotherapy represents the first line of therapy for genital warts that has been reported previously as a method with a high success rate in healing genital warts, and it decreases the concentration of HPV virus and removes the trigger that allows the development of cancer. Cryotherapy usually require local anesthesia and freezing is performed for each genital wart separately. It is usually followed by side effects such as pain and swelling, and rarely dyspigmentation.