الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Psoriatic arthritis is a chronic inflammatory joint disease associated with PsO. This immune mediated disease, is classified as a seronegative SpA and is characterized by a broad spectrum of clinical manifestations.
Enthesitis is considered the hallmark of PsA. However, the clinical evaluation of enthesitis is challenging, as it may be misdiagnosed as mechanical trauma or FM. The emergence and wider use of musculoskeletal US helps in solving this dilemma.
Recent studies suggest that serum CLP levels can monitor disease activity and treatment response in several inflammatory and autoimmune disease such as systemic lupus erythematosus, RA and PsA.
The aim of this work was to investigate the association between serum CLP level and clinical, functional, and US characteristics of enthesitis in PsA patients.
The current study was conducted on 45 adult PsA patients fulfilling the CASPAR classification criteria and 45 age, sex and BMI-matched healthy controls. All PsA patients were subjected to thorough clinical examination and disease activity assessment using several disease activity scores including the DAPSA, CPDAI and BASDAI. PsO was assessed using PASI. Furthermore, patients’ functional ability was assessed by HAQ-DI and fatigue by the MAF scale. Co-existing FM was assessed by 2016 revisions to the 2010/2011 FM diagnostic criteria. CRP, serum UA and serum CLP levels were measured. Moreover, enthesitis was assessed clinically by the SPARCC and SPARCC plus one indices and sonographically by the MASEI scoring system.