الفهرس | Only 14 pages are availabe for public view |
Abstract Glaucoma affects more than 70 million people worldwide with approximately 10% being bilaterally blind, making it the cause of irreversible blindness in the world. With the growing burden of glaucoma, we looked for better tools for early diagnosis and monitoring. Optical coherence tomography angiography (OCTA) is one of the latest non-invasive imaging technique for studying the vasculature of the retina, the optic nerve, and the peripapillary region. It has been shown that glaucoma is related to the reduction in ocular blood flow but before the advent of OCTA, this has been a difficult area to study. Most of the previous studies of OCTA in glaucoma looked at the vessel density (VD) of the optic nerve head and the peripapillary region. The aim of this study is to evaluate early macular circulation changes in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). One hundred-fifty two eyes of ninty-one female and sixty-one male participants were enrolled in this study. Participants were divided into four groups, participants of open angle glaucomatous eyes, normal- tension glucomatous eyes, ocular hyper tension eyes and normal eyes, each of them included 38 eyes. There were statistically significant difference in BCVA between open angle glaucoma, normal tension glaucoma subjects (p<0.001), and those with ocular hyper tension and normal subjects. Statistically significant decrease in both mean RNFL thickness and GCC were detected in open angle glaucoma and normal tension glaucoma subjects (p<0.001), compared to ocular hypertension and normal subjects. The results of our study showed a statistically significant decrease in VD in both, superficial and deep macular regions in open angle glaucoma and normal tension glaucoma subjects (p<0.001), while showed no evidence of decreased macular perfusion in ocular hyper tension subjects. Also our results showed no statistically difference in FAZ diameter between glaucoma, normal and ocular hyper tension subjects (p=0.173). All of this signify the potential role of OCTA in both diagnosing and monitoring glaucoma, and get OCTA a foothold in more future studies evaluating its usefulness. |