الفهرس 
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Abstract
The World Health Organization defines Type 2 Diabetes Mellitus (T2DM) as a metabolic disorder with multiple genetic and environmental factors that is characterized by chronic hyperglycemia and disturbances in the metabolism of carbohydrate, lipid, and protein as a result of defects in insulin secretion, insulin action, or both. Its prevalence is estimated to be as high as 8.3% worldwide, and it’s predicted to increase to 9.5% by 2030.
Chronic hyperglycemia results in micro- and macrovascular complications in patients with type 2 DM. The increased platelet activity has been implicated as a factor in the development of vascular complications in this metabolic disorder. Moreover, the function of platelets seems to be related to their sizes as large platelets are more reactive, contain greater number of dense granules with more expression of glycoprotein surface receptors, and present increased thrombotic potential.
The aim of this work is to assess platelet activation in patients with type 2 diabetes, controlled and uncontrolled, and its relation with platelet indices.
This comparative cross-sectional study was carried out at the Diabetic Clinic, Internal Medicine Department, and normal controls were recruited from the blood donors coming to the blood bank in Suez Canal University Hospital or healthy individuals attending to the hospital for regular follow-up. All the laboratory work was performed in the Clinical Pathology Department, Suez Canal University Hospital.
The study group included 75 participants measuring activated platelets in