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Abstract Healthcare-associated infections (HCAI) are considered as a major cause of morbidity and mortality, which affect about 1 in 25 hospitalized patients. Healthcare-associated infections can affect patients with indwelling devices in hospitals and other healthcare facilities with higher rates of resistant microorganisms. The most frequent types of HCAI involve central line associated bloodstream infections (CLABSI), catheter-associated urinary tract infections (CAUTIs), surgical site infections (SSIs) and ventilator-associated pneumonia (VAP). Central line-associated bloodstream infections are considered the third most frequent cause of HCAI. Incidence of infection is more in developing countries as compared to developed countries. Mortality rates from CLABSI are 12% to 25% with significantly increase cost and hospital length of stay. CLABSI is defined as a laboratory-confirmed BSI which is not due to an infection at another body site in patients having at least one central line in place for more than 2 calendar days at the time of, or a day before, the onset of the event. |