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Abstract Acute myocardial infarction (AMI) is caused by total, partial, or transitory arterial occlusion caused by atherosclerosis coronary artery plaque types of coronary artery disease (CAD). The hallmarks of this disease are increased ST segments in the reflecting leads and higher cardiac enzymes levels (Reed et al., 2017). MI is a complicated disease marked by the inheritance of many genetic variations that work together with environmental variables to enhance disease progression (Maddhuri et al., 2018). Egypt is the most populated country in the Middle East and North Africa, accounting for almost 15% of the region’s cardiovascular deaths. In Egypt, central obesity and smoking are exceedingly common, resulting to higher burden of pre-acute coronary syndrome (ACS), necessitating customized preventative efforts (Reda et al., 2019). In comparison to other nations in the region and around the world, Egypt has one of the highest rates of CAD- related death. SMARCA4 gene (SWI/SNF related matrix associated, actin dependent regulator of chromatine A4) located on chromosome 19, encodes an ATP-dependent helicase BRG1 and it belongs to SWI/SNF (switching defective/sucrose nonfermenting) complex (Connor et al., 2020). This complex regulate transcription in an ATPdependent manner by disrupting histone –DNA interactions. SMARCA4 is one of the most mutated cancer components (Wilson et al., 2014). Its genetic polymorphisms have been linked to coronary artery disease (CAD) and dyslipidemia-related illness in previous study (Jamaldini et al., 2014; Genena et al., 2023) |