الفهرس | Only 14 pages are availabe for public view |
Abstract .β-thalassemias are a group of recessively inherited hemoglobin disorders characterized by reduced synthesis of β globin chains. Thalassemia constitutes the most common inherited recessive disorder associated with consanguinity, which is a common phenomenon in Egypt. Allo-HSCT is the only established treatment modality that provides a possibility of cure and considered cost effective compared with conventional therapy. Current results of transplantation in pediatrics from matched related donors offer 80% to 87% probability of cure according to risk classes. The thalassemia free survival was respectively 85–90% for class I, 80% for class II, and 70% for class III, while the TRM increased from class I to III. |