الفهرس 
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Abstract
The objectives of the current work were to improve the extent of water solubility and dissolution rate of some active pharmaceutical ingredients (API). Lipid-based Nano systems of Nifedipine, were developed as a comparative study of the formulation of Nanoemulsion and Solid lipid nanoparticle to produce some suitable formulations for improvement of its water solubility. Improvement of Rivaroxaban solubility via the development of Rivaroxaban loaded Nano sponges.
All developed formulations were assessed for the physicochemical properties of the produced particles.
For the Nanoemulsion formulation, a Simple mixing method was employed by dissolving the drug in Caprylic acid as oil phase and Tween 20/ isopropyl alcohol (Smix) then complete to the volume with water to obtain oil/water Nano emulsion. The characteristics of the obtained formulation were evaluated and the effect on the drug solubility, dissolution, and bioavailability was evaluated.
For Solid lipid nanoparticles, the Solvent evaporation technique was utilized by preparing a lipid core of stearic acid, poloxamer 188 as a surfactant, and propylene glycol as a co-solvent then mix with the drug dissolved in ethanol followed by Lyophilization to remove the solvent. Evaluation of the produced formula was carried out to assess the effect on the drug solubility, dissolution, and bioavailability.
Cyclodextrin-based Nanosponge for improvement of Rivaroxaban. Nanosponge is a cross-linked β-Cyclodextrin polymer structured in nano-size forming networks prepared by the solvent technique using N, N-Caronyldiimidazole (CDI) as a cross-linker. The drug was loaded into the prepared Nanosponge with the aid of ultrasonication followed by lyophilization. It provides a promising platform to increase drug solubility, and stability, and enhance the drug release profile. β- Cyclodextrin Nano sponges are cross-linked β-cyclodextrin polymer nanostructured to form three-dimensional networks; exhibit higher complexing ability than natural cyclodextrins toward many molecules.
Keywords: Poorly water-soluble drugs, Drug delivery systems, Nanoemulsion, Solid lipid nanoparticles, Nanosponge.