الفهرس 
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Abstract
Abstract: The objective of this study was to evaluate the beneficial effect of Saccharomyces cerevisiae
(SC) on growth, intestinal morphometric characteristics, blood indices, redox balance, expression
of immune-related genes, and their involvement in disease resistance in sea bream (Sparus aurata).
Three hundred healthy sea bream fingerlings were allocated into equal four groups (15 fish per hapa).
The first group was served as a control and received a basal diet, while the other three groups were
fed diets containing 1, 2, and 4 g/kg diet SC, respectively. At the end of week 16, the daily weight
gain, specific growth rate, and feed utilization were significantly higher in the SC2 and SC4 groups
than the control (p < 0.05). SC dose-dependently improved intestinal morphology, and the 4 g/kg diet
significantly increased dry matter, crude fat, and crude protein percentage of body composition when
compared with the control group. The 4 g/kg SC boosted innate immune response and phagocytic
activity, and all SC-supplemented diets improved total protein, glucose, triglycerides, and urea
concentrations, as well as intestinal digestive enzymatic activities. All estimated oxidative markers
were significantly enhanced in the group that received 4 g/kg SC when compared with the control and
other SC groups (p < 0.05). Feeding the fish a diet supplemented with 4 g/kg SC markedly regulated
the expression of HSP70, IGF1, and IL-1β genes. In addition, the 4 g/kg SC-supplemented diet
was the most effective in protecting the fish against Vibrio parahaemolyticus challenge. In conclusion,
SC-enriched diet improved growth performance, intestinal morphology, redox homeostasis, and
immune response of S. aurata with the 4 g/kg concentration as the most effective.