الفهرس 
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 82 |  |  |
| | | from | 82 | | |
Abstract
Background: Great efforts have been undertaken for dental caries prevention. Among the
recent remineralizing materials, Nano silver fluoride varnish products which are based on
nanotechnology have been proposed for “repairing” enamel . Regenerative medicine-based
approaches for caries treatment focus on biomimetic remineralization of initial carious lesions
as a minimal invasive therapy using Self-Assembling Peptide P11-4 (Curodont Repair) which
enhances remineralization of white spot lesions.
Purpose of the Study: The aim of this study is to compare clinically and microbiologically
the therapeutic effect of Self Assembling Peptide P11-4 (Curodont Repair), nano silver fluoride
varnish and 5% fluoride varnish (Duraflor) on remineralization of enamel White Spot Lesions
in permanent teeth of adults.
Sample: The study will be a randomized controlled double-blinded study conducted on
participants aged 10 to 24 years satisfying the inclusion criteria with visible active white spot
lesions on buccal surfaces of permanent teeth. Sixty six patients will be randomly allocated
into 3 groups of the three materials: study group 1: one application of Curodont Repair, study
group 2: one application of Nano-silver fluoride varnish and Control group twice application
of Fluoride Varnish (Duraflor).
Methods: White spot lesions will be assessed at baseline according to International Caries
Detection and Assessment System- Lesion Activity Assessment (ICDAS-LAA) and saliva
samples will be collected to assess salivary Streptococcus Mutans and Lactobacillus count. The
materials will be applied in compliance with the manufacturers’ instructions. The participants
will be followed up at 3, 6 and 12 months for Visio tactile assessment and DIAGNOdent
measurements. Microbiological analysis will be done at one, 3 and 6 months follow up.
Key words: White spot lesions, nano-silver fluoride varnish, self-assembling peptide, curodont
repair, duraflor fluoride varnish.