الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Identifying and managing neonatal cholestasis (NC) can be challenging, as the patient may initially appear well and gain weight despite cholestasi sHowever, early detection of NC is important, as it may impact the clinical outcome. Parenteral nutrition is an essential component in the management of many newborn infants, admitted to NICU that requires careful clinical and laboratory monitoring. In Assiut University Children Hospital NICU, Out of 114 neonates admitted from 1 /3/2022 to 28/2/2023 on total parentral nutrion for 14 days or more 15 developed cholestasis (group 1) while 99 didn’t develop cholestasis (group 2).the incidence of PNAC in neonates to 13% only. Neonates with major congenital anomaly, cholestasis at birth, diseases associated with cholestasis were excluded from the study There were no significant differences between group1 and group 2 in terms of gender, GA, age at initiation of PN and duration of PN , there were significant differences between group1 and group 2 in terms of bowel resection & NEC &sepsis but subgroup analysis showed that duration of PN was significantly different between the group1 and group 2 groups (P < 0.05),.