الفهرس | Only 14 pages are availabe for public view |
Abstract Meningitis, the most prevalent infectious disease of the CNS is inflammation of the meninges that envelop the brain and spinal cord. A bacterial, viral, or other microbiological infection is the most prevalent underlying cause of meningitis., however, less commonly certain drugs cause such inflammation. To date, no single laboratory test is able to distinguish bacterial meningitis from non-bacterial meningitis with high diagnostic accuracy. There was a paucity of previous studies suggesting that LCN2, a small protein that allowed securing iron by obstructing bacteria’s ability to acquire iron through siderophores, can be used in diagnosing bacterial meningitis. This study sought to find out how effective LCN2 in differentiating between bacterial and non-bacterial meningitis. This was a prospective comparative study conducted on 40 adult patients with suspected meningitis admitted to Alexandria Fever Hospital. According to CSF criteria and clinical manifestations, the 40 patients were classified into two groups; group A, including twenty patients with bacterial meningitis, and group B, including twenty patients with non-bacterial meningitis. |