الفهرس 
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Abstract
sThis work was established to study the diversity of the endophytic fungi, for the first time, associated with fifteen species of wild medicinal plants Anabasis setifera Moq., Bassia muricata (L.) Asch., Calligonum comosum L’Hér., Calotropis procera (Aiton) Dryand., Cornulaca monacantha Del., Fagonia arabica L., Heliotropium bacciferum Frossk., Leptadenia pyrotechnica (Forssk.) Decne, Ochradenus baccatus Del., Pulicaria crispa (Forssk.) Oliv., Salsola baryosma (Schult.) Dandy, Schouwia purpurea (Forssk.) Schweinf., Tamarix nilotica (Ehrenb.) Bunge., Zilla spinosa (L.) Prantl and Zygophyllum coccineum L. Then, we used ethyl acetate to extract the major bioactive compounds that were secreted by the fungi and evaluated the biological activities of the crude extract.
A total of twenty-nine species related to seventeen fungal genera were recovered as endophytic fungi from healthy wild medicinal plant samples using Potato Dextrose Agar (PDA) medium. Aspergillus, Nigrospora, and Alternaria were recorded as the most prevalent fungal genera in this survey. Moreover, there are some fungal species that were isolated only from a specific plant such as Paecilomyes sp. isolated only form Cornulaca stem samples and Beauveria bassiana only from Tamarix leaves.
We isolated a new strain of Beauveria sp. AUMC 15401 and studied their effect on the alkaloid production of tomato leaves after the colonization event. The alkaloidal extract exhibited promising cytotoxic activity against A549 cell lines. We used molecular docking to assess the inhibitory affinities of different alkaloids against EGFR, VEGFR2, and SRC the main proteins involved in lung cancer progression. ADME analysis has been conducted to evaluate the potential of the alkaloids to be oral active drugs. Thus, we believe that colonization of Beauveria sp.