الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
latinum-based drugs have revolutionized treatment of solid tumors of
organs such as ovarian, head and neck, lung, brain, and testis. This compound
stops mitosis and induces apoptosis. Cisplatin (CP) is thought to kill cancer
cells primarily by forming DNA adduct, causing G2 cell cycle arrest, and
finally triggering apoptosis. Some of the most important side effects of
cisplatin are nephrotoxicity, hepatotoxicity, ototoxicity, neurotoxicity,
cardiotoxicity, and tesiculartoxicity.
Gum Arabic (GA) is produced from dried exudates of Acacia
senegal and Acacia seyal and is rich in high molecular weight heterogeneous
gum polysaccharides and contains calcium and magnesium. It is widely used
as a vehicle for pharmacological experiments and is assumed innocuous and
has antioxidants and other beneficial activities in specific contexts. This study
aimed to declare the naughty impact of CP on testes and liver tissues of male
albino rats. Also, to illustrate the meliorative effects of GA on liver and testes
tissues. So, biochemical, histological, ultrasturcturl and immunohistochemical
investigations were carried out.
Forty male albino Sprague Dawley rats (Rattus norvegicus) weighing rats
(135-140g) and of 9-10 weeks of age were used as expirmental animals. The rats
were randomly and equally divided into four groups (10 rats each):
Control group (G1): included normal animals that did not receive any
treatment during the experimental period.
Gum Arabic group (G2): included animals that orally received an
aqueous solution of freshly prepared GA; (7.5mg GA/kg rat BW/day) using a
stomach tube for four weeks