الفهرس 
I. Introduction and Aim of the WorkOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
Preeclampsia (PE) is characterized by new onset hypertension and proteinuria. Undoubtedly, some individuals do not fit precisely into this description, and it could be challenging to spot newly developed PE in females who already have hypertension and/or renal illness. Monitoring the disease’s progression enables the optimization of delivery time while minimizing premature births. The current study explores the diagnostic benefits of serum endostatin and cystatin C in addition to serum and urinary magnesium (Mg) and fractional excretion magnesium (FEMg) for early prediction of PE. The population sample included 82 Egyptian women. The participants were divided into 3 groups; control (n= 26), Non-preeclampsic (NPE, n = 34) and preeclampstic (PE, n= 22) groups. Blood samples were withdrawn at two sampling time: at 12th – 16th weeks and 24th-26th weeks of gestation. Compared to normal control group, results indicated significant increase in serum endostatin in NPE (X̄ ± SD at first sample = 10.78 ± 3.63, at second sample = 28.03 ± 3.79) and cystatin C (X̄ ± SD at first sample = 0.68 ± 0.06, at second sample = 0.71 ± 0.07). In PE group, the X̄ ± SD of serum endostatin was 18.86 ± 4.37 at first sampling time and 53.56 ± 9.76 at second sample. Serum cystatin C was also elevated in PE with X̄ ± SD equivalent to 0.73 ± 0.08 and 0.89 ± 0.08 at first and second sample, respectively. On the other hand, serum and urinary Mg in addition to FEMg levels did not significantly differ across the groups under study. Roc curve analysis proved that both endostatin and cystatin C could be good indicators for PE. The findings from this work imply that measuring endostatin and cystatin C in the second and third trimesters and before the progression to PE may be effective in detecting the likelihood of PE. Endostatin could be more precise and sensitive in assessing the likelihood of PE than cystatin C, however coupling of the two parameters may be promising.