الفهرس 
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Abstract
Aim: the current study adopted to assess the pubertal growth spurt by evaluating the urinary insulinlike growth factor 1 (UIGF-1) in Egyptian females and males and estimate the mean chronological
age at the peak of urinary IGF-1 in both genders.
Methodology: A total sample of 156 subjects was recruited from the orthodontic department of the
faculty of dentistry- Cairo university. They were equally divided into 78 males and 78 females with
the age range of males (10-16 years) and females (8-14 years). Each gender was further subdivided
into three age subgroups males (10-12), (12-14), and (14-16), females (8-10), (10-12), and (12-14).
Lateral cephalograms were taken from the subjects for cervical vertebral assessment according to
Baccetti et al. and assessed twice by the same rater with a one-week interval and one assessment by
another rater. Fresh morning urine samples were collected from subjects to quantify the concentration
of IGF-1 by ELIZA technique.
Results: a comparison between the UIGF-1 and CVM and between UIGF-1 and age subgroups was
statistically analyzed in both genders. from the UIGF-1 curve, it was shown in males and females the
peak of UIGF-1at CVM 4, which was significantly different from the mean values of other CVM
stages (P ˂0.05). Females reach the peak UIGF-1 value at 12.23 years while males at the age
of 13.84 years. UIGF-1 at CVM 3 was preceded the CVM 4 representing the onset of a growth
spurt with the mean age of 12.92 years in males and 11.24 years in females.
Conclusion: UIGF-1 is compatible with CVM stages. Thus, it is a reliable biological indicator
employed in orthodontics for growth spurt assessment of both genders. Females mature from 1 to 2
years earlier than males.