الفهرس | Only 14 pages are availabe for public view |
Abstract Synthesis of Some New Diethyl α-Aminophosphonate Derivatives Bearing Bioactive Heterocycles as Antiagricultural Pests We displayed the synthesis of some novel bioactive quinolinyl, chromonyl and 1,3-diarylpyrazole α-aminophosphonate esters clubbed with nitrogen heterocycles in one molecular frame which showed enhanced biological activity. The methodology depended on the design of these novel α-aminophosphonates scaffold by one-pot three-components of aldehyde, amine and diethyl phosphite in the presence of CdI2 nanoparticles as an efficient catalyst under conventional at 80 oC or ultrasound (US) irradiation at 50 oC. All obtained products were characterized by spectroscopic methods and elemental analysis. In addition, all the synthesized products were evaluated in vitro for their antifungal activities. Part I: Design of Novel Quinolin-4-one α-Aminophosphonate Derivatives Under Ultrasonic Irradiation Using CdI2 Nanoparticles as an Efficient Catalyst: Synthesis, characterization and Antifungal Properties Two series of ten novel α‐aminophosphonate esters 2a-e, 4, 6, 8, 10 and 12 that incorporated 4-oxo-quinoline moiety, were designed by the Kabachnik–Fields reaction. Diethyl {(4-oxo-1,4-dihydroquinolin-3-yl) (arylamino)methyl}phosphonates (2a-e) were obtained in excellent yields by reaction of 4-oxo-1,4-dihydroquinoline-3-carboxaldehyde (1) with different substituted anilines and diethyl phosphite under conventional at 80 oC or ultrasound (US) irradiation at 50 oC in the presence of CdI2 nanoparticles (10 mol%) (Scheme 1) |