الفهرس 
INFLAMMATORY BOWEL DISEASE (IBD)Only 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: A bidirectional relationship exists between infections and the development of IBD. Early diagnosis of infection in a relapse may reduce a patient’s unnecessary exposure to corticosteroids and/or immunosuppressive drugs and it may also hasten their time to recovery.
Aim of the work: The aim of the present study is to assess the microbiological causes of relapses in IBD patients including clostridium difficile infection.
Patients and Methods: This was a cross sectional study included 50 known children with IBD who were following up at pediatric gastroenterology unit, Ain Shams University Hospitals, and presented with acute relapse. All patients were subjected to history taking of socio-demographic characteristics, clinical signs & symptoms, medications including IBD therapy and recent antibiotics, laboratory investigations including blood tests, stool analysis and culture & sensitivity. Clostridium difficile toxin A and B test was done via rapid chromatographic immunoassay in fecal specimens.
Results: The included patients were of mean age ± 12.45 years, 30 males and 20 females. Stool culture and sensitivity showed 86% no growth, 10% E.coli, 2% Salmonella and 2% E. Histolytica. Clostridium difficile infection (CDI) was positive in 40% of included children. Children who were tested positive for CDI had high frequency of recent antibiotic use (P= 0.036), associated DM (p = 0.004) and presence of RBCs in stool (P= 0.038).
Conclusion: Clostridium difficile infection is an important infection in cases of relapsed IBD, which is often overlooked in pediatrics. This risk might be increased with previous intake of antibiotics and associated immunological diseases (DM).